World No. 16 Marco Cecchinato will spearhead Italy's challenge, while they also have the experienced world No. 37 Andreas Seppi as they look to continue their good record against India.
A look at the records of Spain's Rafael Nadal and Serbia's Novak Djokovic before their title clash at the Australian Open on Sunday (prefix number denotes seeding):
Images from Day 1 of the US Open in New York, on Monday.
Change might be afoot though, according to American great John McEnroe
Milos Raonic has been called the present and future of Canadian tennis for years, and on Friday he realised his potential with a milestone semi-final victory at Wimbledon to cement his status as one of the game's rising stars. Raonic appeared to be down and out as he trailed Federer by two-sets to one and 15-40 in the fifth game of the fourth set but somehow he managed to cling on for a 6-3 6-7(3) 4-6 7-5 6-3 win and became the first Canadian man to reach a major final.
India's World Group hopes suffered a huge setback as Rohan Bopanna and Purav Raja lost the crucial doubles rubber to hand Canada a 2-1 lead in the Davis Cup Play-off tie, in Edmonton, on Sunday.
Team Europe swept the singles matches at the inaugural Laver Cup on Friday before Australian Nick Kyrgios and American Jack Sock took down top-ranked Rafael Nadal and Tomas Berdych in the doubles to salvage a point for Team World.
It was Kristyna's first win over a top-five ranked player and she will go on to play fellow Czech Barbora Strycova in the quarter-finals.
Images from Day 2 at the US Open played at Flushing Meadows in New York on Tuesday
amiliar names, however, are tipped to take off with the winners' trophies. The following is a list of talking points at the Australian Open:
With rain having washed out Wednesday's play, Federer along with champion Rafael Nadal and top seed Novak Djokovic all face playing back-to-back matches on Thursday if they want to reach the quarter-finals.
Images from Day 5 of the US Open in New York on Friday
Eugenie Bouchard's mid-season nosedive continued on Tuesday as the Canadian was swept aside 6-3 6-4 by Croatian qualifier Donna Vekic despite having home advantage and the backing of an excited crowd in a first round clash at the Rogers Cup.
World number one Novak Djokovic was sensationally disqualified in the US Open fourth round on Sunday after striking a line judge with a ball following a point during the first set of his match against Spain's Pablo Carreno Busta.
Roger Federer suffered a shock 3-6, 6-3, 7-6(4) defeat to Australian wildcard Thanasi Kokkinakis on Saturday that will cost the Swiss his world number one ranking and leaves the Miami men's tournament wide open.
Second seed Sloane Stephens was shocked 2-6, 6-4, 6-2 by Germany's Andrea Petkovic in the second round of the Citi Open on Wednesday, disrupting the American's buildup to her US Open title defence.
Defending champion Djokovic fired his 15th ace on match point to defeat Querrey but his serve had been an issue earlier in their second-round encounter.
Halep through but Stephens exits in Cincinnati
Maria Sharapova will be back in the US Open spotlight on Wednesday hoping she can come up with a winning encore to her electrifying first round victory over second seed Simona Halep.
Images from Day 7 of the 2022 French Open at Roland Garros in Paris on Saturday.
IMAGES from Day 3 of the US Open in New York on Wednesday.
Novak Djokovic destroyed a woeful Stefanos Tsitsipas 6-1, 6-2 to book his place in the semi-finals of the Paris Masters.
The future arrived late but after some old-fashioned glitches, two Russian trailblazers fired the first shots in what could be a revolution in tennis at the Next Gen ATP Finals on Tuesday.
Alexander Zverev got the better of older brother Mischa at the Citi Open in Washington on Thursday, winning their first meeting at an ATP Tour event 6-3, 7-5.
For all their celebrated Grand Slam past, Nadal and Federer have never clashed in a US Open final.
Milos Raonic overcame third seed Grigor Dimitrov 7-5, 3-6, 6-3 to reach the third round at the Madrid Open on Tuesday and set up an all-Canadian clash with teenager Denis Shapovalov.
The top-seeded Serb, who had not dropped a set in four matches since the round of 16 at the Australian Open in January, looked out-of-sorts throughout the 98-minute contest.
A summary of sports events and sports persons, who made news on Tuesday
Former world number one Serena Williams looked sharp in her return to the hardcourts after a week-long break, soundly defeating Daria Gavrilova 6-1, 6-2 on Monday to advance to the second round of the Cincinnati Masters.
Images from Day 6 of Wimbledon at the All England Lawn Tennis and Croquet Club in London, on Saturday.
Cycling: Olympic champion Vogel stable after operation
IMAGES from the Miami Masters played in Key Biscayne, Florida on Tuesday
A day after celebrating his 36th birthday, Federer played the aggressive game that has propelled him to five titles, including two grand slams, this year, attacking the net and rocketing second serves.
Images from Day 2 of the Australian Open in Melbourne on Tuesday
The Big Four were always going to come into the year's first Grand Slam knowing fully well that their days of dominance are drawing to a close, if not already a thing of the past, says Dhruv Munjal.
World number one Rafael Nadal set a new record of winning 50 consecutive sets on a single surface by beating Argentine Diego Schwartzman 6-3, 6-4 on Thursday to reach the Madrid Open quarter-finals.
World number two Rafael Nadal dropped a set at the Barcelona Open for the first time in four years before advancing to the last 16, beating Argentine Leonardo Mayer 6-7(7), 6-4, 6-2 on Wednesday.
Summary of sports events and persons who made news on Wednesday
Earlier on Wednesday, Czech Karolina Pliskova was forced to withdraw from the tournament due to a viral illness.
Summary of sports events and persons who made news on Wednesday